Stem cell library screen identified ruxolitinib as regulator of osteoblastic differentiation of human skeletal stem cells.
Nihal AlMuraikhiDalia AliAliah AlshanwaniRadhakrishnan VishnubalajiMuthurangan ManikandanMuhammad AtteyaAbdulaziz SiyalMusaad AlfayezAbdullah AldahmashMoustapha KassemNehad M AlajezPublished in: Stem cell research & therapy (2018)
We identified ruxolitinib as an important regulator of osteoblast differentiation of hMSCs. It is plausible that inhibition of osteoblast differentiation by ruxolitinib may represent a novel therapeutic strategy for the treatment of pathological conditions caused by accelerated osteoblast differentiation and mineralization.