Ectopic nerve growth factor prevents proliferation in glioma cells by senescence induction.

Daniela MecoAngela Maria Di FrancescoLinda MelottiAntonio RuggieroRiccardo Riccardi

Published in: Journal of cellular physiology (2018)

These findings provide the first evidence that NGF can induce senescence of PLGG cells in a receptor-mediated fashion, thus supporting the hypothesis that in the clinical setting NGF might be beneficial to pediatric glioma patients.

Keyphrases

growth factor
end stage renal disease
dna damage
endothelial cells
ejection fraction
induced apoptosis
chronic kidney disease
prognostic factors
peritoneal dialysis
patient reported outcomes
mouse model
cell proliferation
childhood cancer