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Clinicopathological significance of ataxia telangiectasia-mutated (ATM) kinase and ataxia telangiectasia-mutated and Rad3-related (ATR) kinase in MYC overexpressed breast cancers.

Constantinos SavvaKaren De SouzaReem AliEmad A RakhaAndrew R GreenSrinivasan Madhusudan
Published in: Breast cancer research and treatment (2019)
We conclude that ATR/ATM-directed stratification and personalisation of therapy may be feasible in MYC overexpressed breast cancer.
Keyphrases
  • dna damage response
  • dna repair
  • dna damage
  • protein kinase
  • early onset
  • transcription factor
  • tyrosine kinase
  • wild type
  • oxidative stress
  • mesenchymal stem cells
  • childhood cancer