Effectiveness and safety of primary prophylaxis with G-CSF during chemotherapy for invasive breast cancer: a systematic review and meta-analysis from Clinical Practice Guidelines for the Use of G-CSF 2022.
Kazuki NozawaYukinori OzakiTetsuhiro YoshinamiTakamichi YokoeHiroshi NishioKenji TsuchihashiEiki IchiharaYuji MiuraMakoto EndoShingo YanoDai MaruyamaNobuyuki SusumuMunetaka TakekumaTakashi MotohashiMamoru ItoEishi BabaNobuaki OchiToshio KuboKeita UchinoTakahiro KimuraYutaro KamiyamaShinji NakaoShinobu TamuraHitomi NishimotoYasuhisa KatoAtsushi SatoToshimi TakanoPublished in: International journal of clinical oncology (2024)
Primary prophylactic use of G-CSF is strongly recommended for breast cancer patients undergoing chemotherapy, as it has been shown to reduce the incidence of FN. While the impact on OS is unclear, the benefits of reducing FN are considered to outweigh the potential harm of increased pain.