A Revised Molecular Model of Ovarian Cancer Biomarker CA125 (MUC16) Enabled by Long-read Sequencing.

Chien-Wei Wang Simon D Weaver Nicha Boonpattrawong Naviya Schuster-Little Manish Suresh Patankar Rebecca J Whelan

Published in: Cancer research communications (2024)

Despite its crucial role in clinical management of ovarian cancer, the exact molecular sequence and structure of the biomarker, CA125, are not defined. Here, we combine long-read sequencing, mass spectrometry, and in silico modeling to provide the foundational dataset for a more complete characterization of the CA125 epitope.

Keyphrases

single molecule
mass spectrometry
single cell
protein kinase
molecular docking
high resolution
density functional theory
monoclonal antibody
simultaneous determination