The lncRNA LAMP5-AS1 drives leukemia cell stemness by directly modulating DOT1L methyltransferase activity in MLL leukemia.

Wen-Tao WangTian-Qi ChenZhan-Cheng ZengQi PanWei HuangCai HanKe FangLin-Yu SunQian-Qian YangDan WangXue-Qun LuoYu-Meng SunYue-Qin Chen

Published in: Journal of hematology & oncology (2020)

This is the first study that a lncRNA regulates the self-renewal program and differentiation block in MLL leukemia cells by facilitating the methyltransferase activity of DOT1L and global H3K79 methylation, showing its potential as a therapeutic target for MLL leukemia.

Keyphrases

acute myeloid leukemia
bone marrow
induced apoptosis
long non coding rna
signaling pathway
single cell
dna methylation
protein protein
cell cycle arrest
long noncoding rna
cell therapy
mesenchymal stem cells
endoplasmic reticulum stress
small molecule
energy transfer
quantum dots