Low-intensity extracorporeal shock wave therapy promotes myogenesis through PERK/ATF4 pathway.

Bohan WangJun ZhouLia BanieAmanda B Reed-MaldonadoHongxiu NingZhihua LuYajun RuanTie ZhouHsun Shuan WangByung Seok OhGuifang WangStanley Lei QiGuiting LinTom F Lue

Published in: Neurourology and urodynamics (2017)

In conclusion, this experiment reveals that rat uMDSCs can be isolated successfully and can form myotubes in vitro. PERK/ATF4 pathway was involved in myotube formation, and L6 rat myoblast cells were activated by Li-ESWT to form myotubes. These findings suggest that PERK/ATF4 pathway is activated by Li-ESWT. This study elucidates one of the biochemical pathways responsible for the clinical improvements seen after Li-ESWT. It is possible that this information will help to establish Li-ESWT as an acceptable treatment modality and may help to further refine the use of Li-ESWT in the clinical practice of medicine.

Keyphrases

endoplasmic reticulum stress
induced apoptosis
ion batteries
clinical practice
transcription factor
solid state
oxidative stress
endoplasmic reticulum
stem cells
healthcare
health information
cell proliferation
mesenchymal stem cells
smoking cessation