OMTX705, a Novel FAP-Targeting ADC Demonstrates Activity in Chemotherapy and Pembrolizumab-Resistant Solid Tumor Models.

Myriam FabreCristina FerrerSaioa Domínguez-HormaetxeBruno BockornyLaura MuriasOliver SeifertStephan A EislerRoland E KontermannKlaus PfizenmaierSo Young LeeMaría dM VivancoPedro P López-CasasSofia PereaMuhammad AbbasWolfgang RichterLaureano SimonManuel Hidalgo

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

These data suggest that FAP targeting with OMTX705 represents a novel and potent strategy for cancer treatment, including tumors resistant to immunotherapy, and support its clinical development.

Keyphrases

cancer therapy
electronic health record
big data
advanced non small cell lung cancer
magnetic resonance imaging
locally advanced
radiation therapy
machine learning
anti inflammatory
computed tomography
diffusion weighted imaging
artificial intelligence
tyrosine kinase