Physiologically Based Pharmacokinetic Modeling Approach to Identify the Drug-Drug Interaction Mechanism of Nifedipine and a Proton Pump Inhibitor, Omeprazole.

Maxime Le MerdyMing-Liang TanDajun SunZhanglin NiSue-Chih LeeAndrew BabiskinLiang Zhao

Published in: European journal of drug metabolism and pharmacokinetics (2021)

The developed full PBPK model with the capability to simulate DDI by considering gastric pH change and metabolic inhibition provides a mechanistic understanding of the observed DDI of nifedipine with a PPI, omeprazole.

Keyphrases

adverse drug
drug induced
emergency department