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Oxidative stress and inflammation are associated with age-related endothelial dysfunction in men with low testosterone.

Matthew C BabcockLyndsey E DuBoseTeresa L WittenBrian L StaufferKerry L HildrethRobert S SchwartzWendy M KohrtKerrie L Moreau
Published in: The Journal of clinical endocrinology and metabolism (2021)
Healthy MA/O men with low testosterone appear to have greater age-associated endothelial dysfunction, related in part to greater oxidative stress and inflammation. These data suggest that low testosterone concentrations may contribute to accelerated vascular aging in men.
Keyphrases
  • oxidative stress
  • replacement therapy
  • middle aged
  • dna damage
  • ischemia reperfusion injury
  • diabetic rats
  • electronic health record
  • smoking cessation
  • endoplasmic reticulum stress