Blood-based multivariate methylation risk score for cognitive impairment and dementia.
Jarno KoetsierRachel CavillRick ReijndersJoshua HarveyJan HomannMorteza KouhsarKay DeckersSebastian KöhlerLars M T EijssenDaniel L A van den HoveIlja DemuthSandra Düzelnull nullRebecca G SmithAdam R SmithJoe BurrageEmma M WalkerGemma ShirebyEilis HannonEmma DempsterTim FraylingJonathan MillValerija DobricicPeter JohannsenMichael WittigAndre FrankeRik VandenbergheJolien SchaeverbekeYvonne Freund-LeviLutz FrölichPhilip ScheltensCharlotte E TeunissenGiovanni FrisoniOlivier BlinJill C RichardsonRégis BordetSebastiaan EngelborghsEllen de RoeckPablo Martinez-LageMikel TaintaAlberto LleóIsabel SalaJulius PoppGwendoline PeyratoutFrans VerheyMagda TsolakiUlf AndreassonKaj BlennowHenrik ZetterbergJohannes StrefferStephanie J B VosSimon LovestonePieter-Jelle VisserChristina M LillLars BertramKatie LunnonEhsan PishvaPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
We used whole blood DNA methylation as a surrogate for 14 dementia risk factors. Created a multivariate methylation risk score for predicting cognitive impairment. Emphasized the role of machine learning and omics data in predicting dementia. The score predicts cognitive impairment development at the population level.