Benefits of bone marrow mesenchymal stem cells compared to their conditioned medium in valproic acid-induced autism in rats.

Mehrazin Noshadian Iraj Ragerdi Kashani Reza Asadi-Golshan Davood Zarini Neda Ghafari Elham Zahedi Parichehr Pasbakhsh

Published in: Molecular biology reports (2024)

Post-developmental administration of BM-MSCs and BM-MSCs-CM can ameliorate prenatal neurodevelopmental deficits, restore cognitive and social behaviors, and modulate microglial and inflammatory markers. Results indicated that the improvement rate was higher in the BM-MSCs group than BM-MSCs-CM group.

Keyphrases

mesenchymal stem cells
umbilical cord
pregnant women
healthcare
autism spectrum disorder
traumatic brain injury
inflammatory response
bone marrow
intellectual disability
lipopolysaccharide induced
lps induced
spinal cord injury
congenital heart disease