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A pH-activated fluorescent probe via transformation of azo and hydrazone forms for lysosomal pH imaging.

Xiao-Lei ZhaoChenxu YanWan-Shan QiuTao YuWu-Jin WangWei-Hong Zhu
Published in: Chemical communications (Cambridge, England) (2022)
We developed a fluorescent probe Sth-NH by introducing a 6-hydroxypyridone skeleton. The presence of an active proton enables the probe to transform from a deprotonated azo form to a hydrazone form in a strongly acidic environment to realize fluorescence light-up behavior, thus monitoring the lower lysosomal pH of cancer cells and distinguishing them from normal cells.
Keyphrases
  • fluorescent probe
  • living cells
  • single molecule
  • induced apoptosis
  • high resolution
  • cell cycle arrest
  • ionic liquid
  • signaling pathway
  • room temperature
  • cell death