Antinociceptive Effect of Lodenafil Carbonate in Rodent Models of Inflammatory Pain and Spinal Nerve Ligation-Induced Neuropathic Pain.
Marcio Carneiro VieiraFernanda Bezerra de Mello MonteBruno Eduardo DematteTadeu Lima MontagnoliGuilherme Carneiro MontesJaqueline Soares da SilvaRosália Mendez-OteroMargarete Manhães TrachezRoberto Takashi SudoGisele Zapata-SudoPublished in: Journal of pain research (2021)
Lodenafil carbonate demonstrates important analgesic activity by promoting presynaptic hyperpolarization and preventing neuroplastic changes, which may perpetuate chronic pain, thus representing a potential treatment for neuropathic pain.