Effect of Intramyocardial Administration of Baculovirus Encoding the Transcription Factor Tbx20 in Sheep With Experimental Acute Myocardial Infarction.
María Rosario Del BauzáAyelén Emilce LópezJorge Alejandro SimoninFrancisco Stefano CimbaroAgustina ScharnAraceli CastroCintia Virginia SilvestroLuis Alberto CunibertiAlberto José CrottoginiMariano Nicolás BelaichPaola LocatelliFernanda Daniela OleaPublished in: Journal of the American Heart Association (2024)
In sheep with AMI, Bv-Tbx20 induced angioarteriogenesis, cardiomyocyte cell cycle activity, infarct size limitation, and a slight recovery of left ventricular function, suggesting that Bv-Tbx20 gene therapy may contribute to cardiac regeneration following AMI.
Keyphrases
- acute myocardial infarction
- cell cycle
- left ventricular
- gene therapy
- transcription factor
- cell proliferation
- lps induced
- high glucose
- percutaneous coronary intervention
- lipopolysaccharide induced
- hypertrophic cardiomyopathy
- stem cells
- cardiac resynchronization therapy
- heart failure
- mitral valve
- aortic stenosis
- left atrial
- inflammatory response
- dna binding
- endothelial cells
- drug induced
- coronary artery disease
- angiotensin ii
- oxidative stress