Broad-Spectrum Antiviral Natural Products from the Marine-Derived Penicillium sp. IMB17-046.
Jiao LiYujia WangXiaomeng HaoShasha LiJia JiaYan GuanZonggen PengHongkai BiChunling XiaoShan CenMaoluo GanPublished in: Molecules (Basel, Switzerland) (2019)
A new pyrazine derivative, trypilepyrazinol (1), a new α-pyrone polyketide, (+)-neocitreoviridin (2), and a new ergostane analogue, 3β-hydroxyergosta-8,14,24(28)-trien-7-one (3), were isolated and characterized along with five known compounds from the marine-derived fungus Penicillium sp. IMB17-046. The structures of these new compounds were determined using spectroscopic data analyses (HRESIMS, 1D- and 2D-NMR), X-ray crystallography analysis, and TDDFT ECD calculation. Compounds 1 and 3 exhibited broad-spectrum antiviral activities against different types of viruses, including human immunodeficiency virus (HIV), hepatitis C virus (HCV), and influenza A virus (IAV), with IC50 values ranging from 0.5 to 7.7 μM. Compounds 1 and 2 showed antibacterial activities against Helicobacter pylori, a causative pathogen of various gastric diseases, with minimum inhibitory concentration (MIC) values of 1-16 μg/mL.
Keyphrases
- hepatitis c virus
- human immunodeficiency virus
- helicobacter pylori
- antiretroviral therapy
- high resolution
- hiv infected
- hiv aids
- hiv positive
- magnetic resonance
- helicobacter pylori infection
- electronic health record
- hiv testing
- computed tomography
- big data
- wound healing
- south africa
- silver nanoparticles
- solid state
- candida albicans
- men who have sex with men
- electron microscopy