A proteomics-metabolomics approach indicates changes in hypothalamic glutamate-GABA metabolism of adult female rats submitted to intrauterine growth restriction.

Amanda Paula PedrosoAna P S DornellasAdriana P de SouzaJosias F PagottoLila M OyamaCláudia M O NascimentoJelena KlawitterUwe ChristiansAlexandre K TashimaEliane Beraldi Ribeiro

Published in: European journal of nutrition (2018)

The present findings suggested that the effects of IUGR on GABA/glutamate-glutamine cycle may be involved in the programming of obesity and hyperglycemia in female rats.

Keyphrases

mass spectrometry
insulin resistance
metabolic syndrome
weight loss
type diabetes
weight gain
high fat diet induced
label free
adipose tissue
young adults
physical activity