Mechanism of Fibrosis in HNF1B-Related Autosomal Dominant Tubulointerstitial Kidney Disease.

Siu Chiu ChanYing ZhangAnnie ShaoSvetlana AvdulovJeremy HerreraKaram AboudehenMarco PontoglioPeter Igarashi

Published in: Journal of the American Society of Nephrology : JASN (2018)

Ablation of HNF-1β in renal epithelial cells leads to the activation of a Twist2-dependent transcriptional network that induces EMT and aberrant TGF-β signaling, resulting in renal fibrosis through a cell-nonautonomous mechanism.

Keyphrases

epithelial mesenchymal transition
transforming growth factor
nuclear factor
single cell
cell therapy
transcription factor
stem cells
liver fibrosis
bone marrow
inflammatory response
atrial fibrillation