High Seroprevalence of Autoantibodies Typical of Autoimmune Liver Disease in Eastern Ethiopia: Is Chewing of Khat (Catha edulis) a Triggering Factor?

Stian Magnus Staurung OrlienTekabe Abdosh AhmedNejib Yusuf IsmaelNega BerheTrine LauritzenSvein Gunnar GundersenAsgeir Johannessen

Published in: Canadian journal of gastroenterology & hepatology (2018)

No association between khat usage and the seropresence of SMA or AMA was found, weakening the hypothesis that khat-related liver injury is mediated through autoimmune mechanisms. However, the seroprevalences of AMA and SMA were strikingly high in this Ethiopian population compared to global estimates, suggesting that diagnostic algorithms for autoimmune liver diseases developed in Europe and North America might lead to misdiagnosis of patients on the African continent.

Keyphrases

drug induced
liver injury
multiple sclerosis
end stage renal disease
ejection fraction
newly diagnosed
machine learning
chronic kidney disease
systemic lupus erythematosus
prognostic factors
south africa
deep learning
patient reported outcomes