The X-linked Becker muscular dystrophy (bmx) mouse models Becker muscular dystrophy via deletion of murine dystrophin exons 45-47.

Christopher R HeierNikki M McCormackChristopher B TullyJames S NovakBreanne L Newell-StamperAlan J RussellAlyson A Fiorillo

Published in: Journal of cachexia, sarcopenia and muscle (2023)

The bmx mouse recapitulates BMD disease phenotypes with histological, molecular and functional deficits. Importantly, it can inform both BMD pathology and DMD dystrophin restoration therapies. This novel model will enable further characterization of BMD disease progression, identification of biomarkers, identification of therapeutic targets and new preclinical drug studies aimed at developing therapies for BMD patients.

Keyphrases

muscular dystrophy
duchenne muscular dystrophy
end stage renal disease
ejection fraction
newly diagnosed
mouse model
bioinformatics analysis
bone marrow
case control
drug induced
patient reported