Genetic associations of docetaxel-based chemotherapy-induced myelosuppression in Chinese Han population.

Weihua RenChenxi ZhouYedong LiuKeli SuLi JiaLuan ChenMo LiJingsong MaWei ZhouSuli ZhangDi ZhangZhiliang CongXuecai NiuShengui ZhangLu ShenCong HuaiXiaofang SunGuorong LiShengying QinLiang Guo

Published in: Journal of clinical pharmacy and therapeutics (2019)

Our findings suggest multiple novel predictive biomarkers of docetaxel-induced myelosuppression: SLC15A1 rs2297322, PXR rs3732359 and FMO3 rs2266782. These discoveries should help in advancing future personalized therapy of docetaxel-based chemotherapy specific to Chinese Han patients.

Keyphrases

chemotherapy induced
locally advanced
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
squamous cell carcinoma
genome wide
diabetic rats
radiation therapy
rectal cancer
oxidative stress
current status
high glucose
copy number