Cytokines regulate stemness of mesenchymal stem cells via miR-628-5p during periodontal regeneration.

Tomoyuki IwataNoriyoshi MizunoTakayoshi NagaharaEri Kaneda-IkedaMikihito KajiyaShinya SasakiKatsuhiro TakedaMari KiyotaRyoichi YagiTsuyoshi FujitaHidemi Kurihara

Published in: Journal of periodontology (2021)

miR-628-5p negatively regulates MSC stemness during periodontal regeneration. Periodontal regenerative cytokines act as miR-628-5p suppressors to support periodontal regeneration. Thus, selection of effective cytokines for different MSCs, based on miRNA profiling, is important for advancing regenerative therapies.

Keyphrases

stem cells
mesenchymal stem cells
cell therapy
umbilical cord
epithelial mesenchymal transition
bone marrow
single cell