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Safety and efficacy of lithium in patients with amyotrophic lateral sclerosis: a systematic review and meta-analysis of randomized controlled trials.

Abdullah Ashraf HamadAmir N AttiaNada Mostafa Al-DarderyShrouk F MohamedMostafa Meshref
Published in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2023)
Current evidence suggests a safety profile with no benefit of lithium for ALS. However, given the limited number of RCTs and the safety findings, we recommend further well-designed RCTs to investigate lithium and valproate in ALS patients.
Keyphrases
  • amyotrophic lateral sclerosis
  • end stage renal disease
  • solid state
  • ejection fraction
  • chronic kidney disease
  • newly diagnosed
  • prognostic factors
  • peritoneal dialysis
  • patient reported outcomes