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The artificial amino acid change in the sialic acid-binding domain of the hemagglutinin neuraminidase of newcastle disease virus increases its specificity to HCT 116 colorectal cancer cells and tumor suppression effect.

Bo-Kyoung JungYong Hee AnSung Hoon JangJin-Ju JangSeonhee KimJoo Hee JeonJinju KimJason Jungsik SongHyun Jang
Published in: Virology journal (2024)
These results provide a new methodology for the use of directed evolution technology for more effective oncolytic virus development.
Keyphrases
  • disease virus
  • amino acid
  • dna binding
  • binding protein
  • transcription factor
  • cell proliferation
  • cell surface