Genistein reverses the effect of 17β-estradiol on exacerbating experimental occlusal interference-induced chronic masseter hyperalgesia in ovariectomised rats.

Yun LiuXiao-Yu ZhangYing-Ying FanXiao-Xiang XuQiu-Fei Xie

Published in: Journal of oral rehabilitation (2021)

Female rats showed greater masseter hyperalgesia than males under EOI. Genistein antagonised the facilitation of EOI-induced chronic masseter hyperalgesia by E2 probably through inhibiting TRPV1 in the TG.

Keyphrases

neuropathic pain
high glucose
drug induced
botulinum toxin
diabetic rats
signaling pathway
spinal cord injury
estrogen receptor
stress induced