Prognostic Significance of CD4+ and CD8+ Tumor-Infiltrating Lymphocytes in Head and Neck Squamous Cell Carcinoma: A Meta-Analysis.

Daniele BorsettoMichele TomasoniKarl PayneJerry Polesel Alberto Deganello Paolo BossiJames R TysomeLiam MastersonGiancarlo TirelliMargherita Tofanelli Paolo Boscolo Rizzo

Published in: Cancers (2021)

The findings from this meta-analysis demonstrate the prognostic significance of CD8+ and CD4+ TILs in HNSCC and variation in tumor subsite warrants further focused investigation. We highlight how TILs may serve as predictive biomarkers to risk stratify patients into treatment groups, with applications in immune-checkpoint inhibitors notable areas for further research.

Keyphrases

systematic review
end stage renal disease
nk cells
ejection fraction
peritoneal dialysis
prognostic factors
peripheral blood
patient reported outcomes
case control