Genetic and multi-omic risk assessment of Alzheimer's disease implicates core associated biological domains.
Gregory A CaryJesse C WileyJake GockleyStephen KeeganSai Sruthi Amirtha GaneshLaura HeathRobert R ButlerLara M MangraviteBenjamin A LogsdonFrank M LongoAllan LeveyAnna K GreenwoodGregory W CarterPublished in: Alzheimer's & dementia (New York, N. Y.) (2024)
This provides an objective methodology to localize risk within specific biological endophenotypes and drill down into the most significantly associated sets of GO terms and annotated genes for potential therapeutic targets.