Genetic and multi-omic risk assessment of Alzheimer's disease implicates core associated biological domains.

Gregory A CaryJesse C WileyJake GockleyStephen KeeganSai Sruthi Amirtha GaneshLaura HeathRobert R ButlerLara M MangraviteBenjamin A LogsdonFrank M LongoAllan LeveyAnna K GreenwoodGregory W Carter

Published in: Alzheimer's & dementia (New York, N. Y.) (2024)

This provides an objective methodology to localize risk within specific biological endophenotypes and drill down into the most significantly associated sets of GO terms and annotated genes for potential therapeutic targets.

Keyphrases

risk assessment
genome wide
human health
cognitive decline
copy number
transcription factor
genome wide identification