In vitro antiplasmodial activity, pharmacokinetic profiles and interference in isoprenoid pathway of 2-aniline-3-hydroxy-1.4-naphthoquinone derivatives.
Valeska S de Sena PereiraFlávio da Silva EmeryLis LoboFátima NogueiraJonas I N OliveiraUmberto L FulcoEudenilson L AlbuquerqueAlejandro M KatzinValter Ferreira de Andrade-NetoPublished in: Malaria journal (2018)
These derivatives have a high potential for the development of new anti-malarial drugs since they showed low toxicity associated to a satisfactory antiplasmodial activity and possible inhibition of a metabolic pathway distinct from the pathways found in the mammalian host.