CircNFATC3 promotes the proliferation of gastric cancer through binding to IGF2BP3 and restricting its ubiquitination to enhance CCND1 mRNA stability.

Feifei YangQiang MaBo HuangXiaolin WangXiaojuan PanTing YuLingyu RanShan JiangHaiping LiYe ChenYuying LiuCe LiangJunwu RenYuying ZhangShimin WangWei LiBin Xiao

Published in: Journal of translational medicine (2023)

Our findings demonstrate that circNFATC3 promotes GC proliferation by stabilizing IGF2BP3 protein to enhance CCND1 mRNA stability. Therefore, circNFATC3 is a potential novel target for the treatment of GC.

Keyphrases

binding protein
signaling pathway
pi k akt
gas chromatography
growth hormone
protein protein
combination therapy
amino acid
small molecule
risk assessment
climate change
tandem mass spectrometry
human health
solid phase extraction