LRRC8A is essential for volume-regulated anion channel in smooth muscle cells contributing to cerebrovascular remodeling during hypertension.

Xiang-Yu LiXiao-Fei LvCheng-Cui HuangLu SunMing-Ming MaCanzhao LiuYong-Yuan Guan

Published in: Cell proliferation (2021)

LRRC8A is an essential component of VRAC and is required for cell volume homeostasis during osmotic challenge in BASMCs. Smooth muscle specific overexpression of LRRC8A increases BASMCs proliferation and substantially aggravates basilar artery remodeling, revealing a potential therapeutic target for vascular remodeling in hypertension.

Keyphrases

smooth muscle
blood pressure
transcription factor
single cell
cell proliferation
signaling pathway
cell therapy
bone marrow
arterial hypertension