Hybrid epithelial-mesenchymal status of lung cancer dictates metastatic success through differential interaction with NK cells.

Monica ParodiGiovanni CentonzeFabio MurianniPaola OrecchiaFrancesca AndrianiIlaria RoatoCecilia GardelliMelissa BalsamoMassimo MoroGiulia TaièUgo PastorinoAndrea PetrettoChiara LavarelloMassimo MilioneGabriella SozziLuca RozMassimo VitaleGiulia Bertolini

Published in: Journal for immunotherapy of cancer (2024)

Our study demonstrates that H-cells play a central role in the metastatic spread in NSCLC. Such pro-metastatic advantage of H-cells is supported by their altered interaction with NK cells and by the critical role of B7-H3 in preserving their H-CIC component, indicating B7-H3 as a potential target in combined NK-based therapies.

Keyphrases

nk cells
small cell lung cancer
induced apoptosis
squamous cell carcinoma
cell cycle arrest
stem cells
endoplasmic reticulum stress
bone marrow
cell death
risk assessment
signaling pathway
advanced non small cell lung cancer
epidermal growth factor receptor