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Hybrid epithelial-mesenchymal status of lung cancer dictates metastatic success through differential interaction with NK cells.

Monica ParodiGiovanni CentonzeFabio MurianniPaola OrecchiaFrancesca AndrianiIlaria RoatoCecilia GardelliMelissa BalsamoMassimo MoroGiulia TaièUgo PastorinoAndrea PetrettoChiara LavarelloMassimo MilioneGabriella SozziLuca RozMassimo VitaleGiulia Bertolini
Published in: Journal for immunotherapy of cancer (2024)
Our study demonstrates that H-cells play a central role in the metastatic spread in NSCLC. Such pro-metastatic advantage of H-cells is supported by their altered interaction with NK cells and by the critical role of B7-H3 in preserving their H-CIC component, indicating B7-H3 as a potential target in combined NK-based therapies.
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