Role of heat shock protein 47 in platelet glycoprotein VI dimerization and signaling.
Sarah K AlOudaParvathy SasikumarTaysseer AlThunayanFahd AlaajamSabeeya KhanKhaled A SahliMohammed S AbohassanAlice PollittStephanie M JungJonathan M GibbinsPublished in: Research and practice in thrombosis and haemostasis (2023)
The present study identifies a role for cell surface-localized HSP47 in modulating platelet responses to collagen through dimerization of GPVI, thereby enhancing platelet signaling and activation.