Cognitive trajectories diverge by genetic risk in a preclinical longitudinal cohort.
Eva VasiljevicRebecca Langhough KoscikErin JonaitisTobey BetthauserSterling C JohnsonCorinne D EngelmanPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2023)
The apolipoprotein E (APOE) score, a continuous measure, accounts for non-linear genetic risk of Alzheimer's disease. Non-linear age interacts with the APOE score to affect cognition. Cognitive decline starts to differ by APOE score levels at approximately age 65. Cognitive decline timing by polygenic risk (including APOE) is similar to APOE alone.