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Pulmonary Fibrosis Stakeholder Summit: A Joint NHLBI, Three Lakes Foundation, and Pulmonary Fibrosis Foundation Workshop Report.

Sydney B MontesiChristian R GomezMichael F BeersRobert BrownIshanu ChattopadhyayKevin R FlahertyChristine Kim GarciaBrigitte N GompertsLida P HaririCory M HogaboamR Gisli JenkinsNaftali KaminskiGrace Hyun J KimMelanie KönigshoffMartin R J KolbDarrell N KottonJonathan A KropskiJoseph LaskyChelsea M MaginToby M MaherMark McCormickBethany B MooreCheryl Nickerson-NutterJustin M OldhamAnna J PodolanczukGanesh RaghuIvan RosasSteven M RoweWilliam T SchmidtDavid A SchwartzJessica E ShoreCathie SpinoJ Matthew CraigFernando J Martinez
Published in: American journal of respiratory and critical care medicine (2024)
Despite progress in elucidation of disease mechanisms, identification of risk factors, biomarker discovery, and the approval of two medications to slow lung function decline in idiopathic pulmonary fibrosis and one medication to slow lung function decline in progressive pulmonary fibrosis, pulmonary fibrosis remains a disease with a high morbidity and mortality. In recognition of the need to catalyze ongoing advances and collaboration in the field of pulmonary fibrosis, the NHLBI, the Three Lakes Foundation, and the Pulmonary Fibrosis Foundation hosted the Pulmonary Fibrosis Stakeholder Summit on November 8-9, 2022. This workshop was held virtually and was organized into three topic areas: 1 ) novel models and research tools to better study pulmonary fibrosis and uncover new therapies, 2 ) early disease risk factors and methods to improve diagnosis, and 3 ) innovative approaches toward clinical trial design for pulmonary fibrosis. In this workshop report, we summarize the content of the presentations and discussions, enumerating research opportunities for advancing our understanding of the pathogenesis, treatment, and outcomes of pulmonary fibrosis.
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