A three-way organelle junction controls PI(4)P metabolism and mitochondrial division.

Published in: The Journal of cell biology (2024)

Membrane contact sites (MCS) facilitate communication between organelles. Casler et al. (https://doi.org/10.1083/jcb.202308144) show that tripartite MCS between mitochondria, the endoplasmic reticulum (ER), and the plasma membrane (PM) regulate mitochondrial division and the distribution of phosphatidylinositol 4-phosphate [PI(4)P] on the PM.

Keyphrases

endoplasmic reticulum
particulate matter
air pollution
oxidative stress
polycyclic aromatic hydrocarbons
heavy metals
water soluble
risk assessment
cell death
estrogen receptor