Applications of Stem Cell-Derived Extracellular Vesicles in Nerve Regeneration.
Burcak YavuzEsra Cansever MutluZubair AhmedBesim Ben-NissanArtemis StamboulisPublished in: International journal of molecular sciences (2024)
Extracellular vesicles (EVs), including exosomes, microvesicles, and other lipid vesicles derived from cells, play a pivotal role in intercellular communication by transferring information between cells. EVs secreted by progenitor and stem cells have been associated with the therapeutic effects observed in cell-based therapies, and they also contribute to tissue regeneration following injury, such as in orthopaedic surgery cases. This review explores the involvement of EVs in nerve regeneration, their potential as drug carriers, and their significance in stem cell research and cell-free therapies. It underscores the importance of bioengineers comprehending and manipulating EV activity to optimize the efficacy of tissue engineering and regenerative therapies.
Keyphrases
- stem cells
- induced apoptosis
- cell therapy
- cell free
- tissue engineering
- cell cycle arrest
- minimally invasive
- mesenchymal stem cells
- endoplasmic reticulum stress
- single cell
- emergency department
- signaling pathway
- climate change
- atrial fibrillation
- social media
- health information
- cell proliferation
- electronic health record