Comparative safety and efficacy of paracetamol versus non-steroidal anti-inflammatory agents in neonates with patent ductus arteriosus: A systematic review and meta-analysis of randomized controlled trials.
Dimitrios N KatsarasGeorgios Ν KatsarasVasiliki I ChatziravdeliGaryfalia N PapavasileiouMaria TouloupakiGeorgios MitsiakosChrysoula DoxaniIoannis StefanidisEfthimios DardiotisPublished in: British journal of clinical pharmacology (2022)
There was no significant difference between paracetamol and ibuprofen or indomethacin in the PDA closure rates. However, paracetamol caused fewer adverse effects.
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