Maintenance darunavir/ritonavir monotherapy to prevent perinatal HIV transmission, ANRS-MIE 168 MONOGEST study.
Laurent MandelbrotRoland TubianaPierre FrangeGilles PeytavinJerome Le ChenadecAna CanestriPhilippe MorlatCécile Brunet-CartierJeanne SibiudeDelphine PerettiVéronique ChambrinAmélie ChabrolEida BuiCaroline Simon-ToulzaLucie MarchandChristelle PaulSandrine DelmasVeronique Avettand-FenoelJosiane Warszawskinull nullPublished in: The Journal of antimicrobial chemotherapy (2023)
Darunavir/ritonavir maintenance monotherapy required intensification in nearly 10% of cases. This limits its widespread use, thus other regimens should be evaluated in order to limit exposure to antiretrovirals, particularly NRTIs, during pregnancy.