Effect of impaired T-cell receptor signaling on the gut microbiota and systemic autoimmunity.

Mirei ShirakashiMikako MaruyaKeiji HirotaTatsuaki TsuruyamaTakashi MatsuoRyu WatanabeKoichi MurataMasao TanakaHiromu ItoHajime YoshifujiKoichiro OhmuraDirk ElewautShimon SakaguchiSidonia FagarasanTsuneyo MimoriMotomu Hashimoto

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2021)

Defective TCR signaling alters the gut microbiota and promotes systemic autoimmunity by driving Th17-cell differentiation.

Keyphrases

celiac disease
regulatory t cells
immune response
drug induced