Comparative Analysis of Clinical Outcomes for COVID-19 and Influenza among Cardiac Transplant Recipients in the United States.
Daniel J ChavarinAniesh BobbaMonique G DavisMargaret A RothMichelle KasdorfAdeel NasrullahPrabal ChourasiaKarthik GanguSindhu Reddy AvulaAbu Baker SheikhPublished in: Viruses (2023)
COVID-19 infections can lead to worse outcomes in an immunocompromised population with multiple comorbidities, e.g., heart transplant patients. We used the National Inpatient Sample database to compare heart transplant outcomes in patients with COVID-19 vs. influenza. A total of 2460 patients were included in this study: heart transplant with COVID-19 ( n = 1155, 47.0%) and heart transplant with influenza ( n = 1305, 53.0%) with the primary outcome of in-hospital mortality. In-hospital mortality ( n = 120) was significantly higher for heart transplant patients infected with COVID-19 compared to those infected with influenza (9.5% vs. 0.8%, adjusted OR: 51.6 [95% CI 4.3-615.9], p = 0.002) along with significantly higher rates of mechanical ventilation, acute heart failure, ventricular arrhythmias, and higher mean total hospitalization cost compared to the influenza group. More studies are needed on the role of vaccination and treatment to improve outcomes in this vulnerable population.
Keyphrases
- end stage renal disease
- coronavirus disease
- heart failure
- sars cov
- ejection fraction
- newly diagnosed
- peritoneal dialysis
- mechanical ventilation
- prognostic factors
- intensive care unit
- acute heart failure
- mental health
- atrial fibrillation
- palliative care
- metabolic syndrome
- insulin resistance
- skeletal muscle
- patient reported outcomes
- patient reported
- extracorporeal membrane oxygenation
- respiratory failure
- glycemic control