Porphyrin Iron-Grafted Mesoporous Silica Composites for Drug Delivery, Dye Degradation and Colorimetric Detection of Hydrogen Peroxide.
Ping ZhuZhihui XuLing CaiJin ChenPublished in: Nanoscale research letters (2021)
Porphyrin iron molecules (hemin) were successfully grafted on the channeled mesoporous silica of SBA-15 (FeIX-SBA-15), in which attached hemin molecules acted as the enzyme mimic for catalyzing oxidation reactions. In the presence of H2O2, the prepared FeIX-SBA-15 composite effectively degraded industrial dye Orange II and catalyzed tetramethylbenzidine hydrochloride (TMB) both in the solution and on the membrane, from which the colorimetric H2O2 detection was achieved. Moreover, the hemin-grafted composites showed high loading content of anticancer drug of doxorubicin hydrochloride (DOX) displaying the sustained releasing behavior as monitored by real-time cell analysis, which resulted in improved inhibitory effect on cancer cells growth compared with that DOX/SBA-15. The hemin-modified mesoporous silica nanocomposite provides an integrated nanoplatform with promising biomedical applications.
Keyphrases
- hydrogen peroxide
- drug delivery
- photodynamic therapy
- aqueous solution
- reduced graphene oxide
- visible light
- nitric oxide
- cancer therapy
- gold nanoparticles
- loop mediated isothermal amplification
- highly efficient
- label free
- real time pcr
- single cell
- drug release
- metal organic framework
- iron deficiency
- wastewater treatment
- electron transfer
- energy transfer
- sensitive detection
- mass spectrometry
- adverse drug
- bone marrow
- quantum dots
- data analysis
- carbon nanotubes
- solid phase extraction