Heme-based oxygen gasoreceptors.

To investigate gasocrine signaling, there is a critical need to identify gasoreceptors for the essential gasotransmitters like O 2 . Based on existing scientific literature, I propose that heme-based O 2 sensors, featuring diverse signaling domains across genera, should be explicitly designated as O 2 gasoreceptors. Acknowledging that O 2 gasoreceptors are likely to belong to multiple protein classes with diverse signaling domains and pathways will facilitate a comprehensive search for O 2 gasoreceptors in all organisms and across every cell type. This approach will broaden the investigation beyond specialized tissues or cells, encompassing a systemic exploration.