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Making the invisible enemy visible.

Tristan I CrollKay DiederichsFlorens FischerCameron FyfeYunyun GaoSam HorrellAgnel-Praveen JosephLuise KandlerOliver KippesFerdinand KirstenKonstantin MüllerKristopher NolteAlexander Matthew PayneMatthew C ReevesJane S RichardsonGianluca SantoniSabrina StäbDale E TronrudLea von SoostenChristopher J WilliamsAndrea Thorn
Published in: bioRxiv : the preprint server for biology (2020)
During the COVID-19 pandemic, structural biologists rushed to solve the structures of the 28 proteins encoded by the SARS-CoV-2 genome in order to understand the viral life cycle and enable structure-based drug design. In addition to the 204 previously solved structures from SARS-CoV-1, 548 structures covering 16 of the SARS-CoV-2 viral proteins have been released in a span of only 6 months. These structural models serve as the basis for research to understand how the virus hijacks human cells, for structure-based drug design, and to aid in the development of vaccines. However, errors often occur in even the most careful structure determination - and may be even more common among these structures, which were solved quickly and under immense pressure. The Coronavirus Structural Task Force has responded to this challenge by rapidly categorizing, evaluating and reviewing all of these experimental protein structures in order to help downstream users and original authors. In addition, the Task Force provided improved models for key structures online, which have been used by Folding@Home, OpenPandemics, the EU JEDI COVID-19 challenge and others.
Keyphrases
  • sars cov
  • high resolution
  • respiratory syndrome coronavirus
  • healthcare
  • coronavirus disease
  • gene expression
  • molecular dynamics simulations
  • amino acid
  • health information
  • quality improvement
  • liquid chromatography