Central angiotensin II type 1 receptor as a therapeutic target against frequent urination.

Shogo Shimizu Takahiro ShimizuYoshiki NagaoYouichirou HigashiMotoaki Saito

Published in: Neurourology and urodynamics (2019)

Central Ang II induced facilitation of the micturition reflex through AT1 and CRF1 receptors. Peripherally administered telmisartan suppressed central Ang II-induced facilitation of micturition reflex.

Keyphrases

angiotensin ii
angiotensin converting enzyme
vascular smooth muscle cells
high glucose
diabetic rats
drug induced
oxidative stress
endothelial cells