Preclinical evidence for the therapeutic value of TBX5 normalization in arrhythmia control.
Franziska S RathjensAlica BlenkleLavanya M IyerAnke RengerFahima SyedaClaudia NoackAndreas JungmannMatthias DewenterKarl ToischerAli El-ArmoucheOliver J MüllerLarissa FabritzWolfram-Hubertus ZimmermannLaura C ZelarayanMaria-Patapia ZafeiriouPublished in: Cardiovascular research (2022)
This study uncovers a novel cardioprotective role of TBX5 in the adult heart and provides preclinical evidence for the therapeutic value of TBX5 protein normalization in the control of arrhythmia.