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Neuroprotection in Acute Ischemic Stroke: A Brief Review.

Alastair M BuchanDavid M Pelz
Published in: The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques (2021)
The goal of effective neuroprotection in acute ischemic stroke remains elusive. Despite decades of experimental preclinical and clinical experience with innumerable agents, no strategy has proven to be beneficial in humans. As endovascular therapies mature and approach the limits of speed and efficacy, neuroprotection will become the next frontier of acute stroke care. This review will briefly summarize the history, preclinical and clinical triumphs and failures, and future directions of cerebral neuroprotection.
Keyphrases
  • cerebral ischemia
  • brain injury
  • subarachnoid hemorrhage
  • healthcare
  • blood brain barrier
  • palliative care
  • cell therapy
  • quality improvement
  • current status
  • mesenchymal stem cells