Epidemiology and outcomes of SARS-CoV-2 infection associated with anti-nucleocapsid seropositivity in Cape Town, South Africa.
Hannah HusseyHelena VreedeMary-Ann DaviesAlexa HeekesEmma KalkDiana HardieGert van ZylMichelle NaidooErna MordenJamy-Lee BamNesbert ZinyakatiraChad M CentnerJean MaritzJessica OpieZivanai ChapandukaHassan MahomedMariette SmithAnnibale CoisDavid PienaarAndrew D ReddWolfgang PreiserRobert WilkinsonKamy ChettyAndrew BoulleNei-Yuan HsiaoPublished in: medRxiv : the preprint server for health sciences (2022)
Inequality and differential access to resources resulted in poorer communities having higher seroprevalence and COVID-19 death rates, with lower case ascertainment rates. Antibody positivity provided strong protection against an immune escape variant like Omicron but came at a high mortality cost.