Risk of cognitive decline progression is associated to increased blood-brain-barrier permeability: A longitudinal study in a memory unit clinical cohort.
Albert Puig-PijoanJoan Jimenez-BaladoAida Fernández-LebreroGreta García-EscobarIrene Navalpotro-GómezJose ContadorRosa-María Manero-BorràsVictor Puente-PerizAntoni SuárezFrancisco J MuñozOriol Grau-RiveraMarc Suárez-CalvetRafael de la TorreJaume RoquerMaria Pilar Gracia ArnillasPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2023)
These results suggest that increased BBBp in individuals with cognitive decline may contribute to clinical worsening, pointing to potential targeted therapies. QAlb could be a useful biomarker for identifying patients with a worse prognosis.