C/EBP homologous protein-induced loss of intestinal epithelial stemness contributes to bile duct ligation-induced cholestatic liver injury in mice.

Runping LiuXiaojiaoyang LiZhiming HuangDerrick ZhaoBhagyalaxmi Sukka GaneshGuanhua LaiWilliam M PandakPhillip B HylemonJasmohan S BajajArun J SanyalHuiping Zhou

Published in: Hepatology (Baltimore, Md.) (2018)

Activation of ER stress and subsequent loss of stemness of ISCs plays a critical role in BDL-induced systemic inflammation and cholestatic liver injury. Modulation of the ER stress response represents a potential therapeutic strategy for cholestatic liver diseases as well as other inflammatory diseases. (Hepatology 2018;67:1441-1457).

Keyphrases

liver injury
drug induced
stem cells
diabetic rats
high glucose
epithelial mesenchymal transition
type diabetes
dna repair
small molecule
signaling pathway
skeletal muscle
liver fibrosis
protein protein