F 1 ·F o ATP Synthase/ATPase: Contemporary View on Unidirectional Catalysis.
Tatyana V ZharovaVera G GrivennikovaVitaliy B BorisovPublished in: International journal of molecular sciences (2023)
F 1 ·F o -ATP synthases/ATPases (F 1 ·F o ) are molecular machines that couple either ATP synthesis from ADP and phosphate or ATP hydrolysis to the consumption or production of a transmembrane electrochemical gradient of protons. Currently, in view of the spread of drug-resistant disease-causing strains, there is an increasing interest in F 1 ·F o as new targets for antimicrobial drugs, in particular, anti-tuberculosis drugs, and inhibitors of these membrane proteins are being considered in this capacity. However, the specific drug search is hampered by the complex mechanism of regulation of F 1 ·F o in bacteria, in particular, in mycobacteria: the enzyme efficiently synthesizes ATP, but is not capable of ATP hydrolysis. In this review, we consider the current state of the problem of "unidirectional" F 1 ·F o catalysis found in a wide range of bacterial F 1 ·F o and enzymes from other organisms, the understanding of which will be useful for developing a strategy for the search for new drugs that selectively disrupt the energy production of bacterial cells.
Keyphrases
- drug resistant
- acinetobacter baumannii
- escherichia coli
- emergency department
- mycobacterium tuberculosis
- gold nanoparticles
- drug induced
- staphylococcus aureus
- high resolution
- signaling pathway
- cell proliferation
- oxidative stress
- pseudomonas aeruginosa
- endoplasmic reticulum stress
- simultaneous determination
- adverse drug